Thank you for your help so far in helping me process our spinal cord data. We have written a paper and have received reviewer comments about the PAM50 template registration. Below is the reviewer comments:
How exactly was the PAM50 template registration performed? Linear or nonlinear registration? Was the spinal cord internal structure accounted for registration? Since the MTR and FA images were registered in the direction from their native space to the PAM50 template space, what data interpolation algorithm was used? For better fidelity of the MTR and FA metrics, would it make more sense to perform the registration in the opposite direction from PAM50 template to the native space? That way, data interpolation would not be needed.
Do you have any thoughts or ways to explain these comments in the response to the reviewers?