Hi everyone,
I am very new to the SCT and I have a question about handling longitudinal spinal cord MRI data. Specifically, I have a cohort of multiple sclerosis patients with brain 3D-T1 scans (acquired at baseline, 6 months and 2 years) with a field of view extending down to C3.
My goal is to quantify SC volume loss over 2 years, and I wanted to ask what you consider the most reliable/state-of-the-art approach for assessing it.
In particular, would you recommend simply calculating the percentage change in MUCCA (i.e., [(MUCCA at 2 years − MUCCA at baseline) / MUCCA at baseline] × 100), or is there a more robust longitudinal framework available, analogous to the halfway-space approach commonly used for brain atrophy measurement (to reduce interpolation bias and improve sensitivity to change)?
Thank you very much for your help!